Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692729 | 0.93 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL5231927 | 0.89 | CYP2C9 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL5231344 | 0.89 | HCRTR1 (0.39) | HCRTR1HCRTR2CCR5SLC22A12MEN1 | |
| SCHEMBL4692413 | 0.87 | HCRTR1 (0.53) | HCRTR1HCRTR2CCR5PLA2G10 | |
| SCHEMBL5233682 | 0.85 | HCRTR1 (0.38) | HCRTR1HCRTR2SLC22A12MEN1KMT2A | |
| SCHEMBL5232788 | 0.84 | CHRNB2 (0.44) | MEN1KMT2APLA2G10PLA2G2AHTR2A | |
| SCHEMBL5237741 | 0.83 | HCRTR1 (0.44) | HCRTR1HCRTR2CCR5PLA2G10 | |
| SCHEMBL5236364 | 0.83 | HCRTR1 (0.47) | HCRTR1HCRTR2CCR5PLA2G10 | |
| SCHEMBL4968486 | 0.83 | HCRTR1 (0.42) | HCRTR1HCRTR2CCR5 | |
| SCHEMBL5235957 | 0.83 | TP53 (0.40) | KMT2APLA2G10PLA2G2ACHRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |