Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202332 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBLMNAKMT2AHPGD | |
| SCHEMBL5235723 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBLMNAKMT2AHPGD | |
| SCHEMBL312497 | 0.80 | POLB (0.69) | SMN1; SMN2POLBLMNAKMT2AHPGD | |
| SCHEMBL5239202 | 0.78 | CYP2A6 (0.50) | SMN1; SMN2POLBLMNAKMT2AHPGD | |
| SCHEMBL5234051 | 0.77 | DYRK1A (0.44) | SMN1; SMN2LMNAKMT2AHPGDRAB9A | |
| SCHEMBL5229048 | 0.77 | LMNA (0.50) | LMNAKMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2977014 | 0.75 | SMN1; SMN2 (0.66) | SMN1; SMN2POLBLMNAKMT2AHPGD | |
| SCHEMBL5198179 | 0.74 | HDAC3 (0.49) | LMNACYP1A2RAB9AGAADYRK1A | |
| SCHEMBL5229628 | 0.74 | SLC9A1 (0.53) | SMN1; SMN2POLBLMNAKMT2ARAB9A | |
| SCHEMBL5235708 | 0.73 | DYRK1A (0.48) | KMT2AHPGDCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461335-B1 | 2-HETEROARYLCARBOXYLIC ACID AMIDES | BAYER HEALTHCARE AG (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1461335-A1 | 2-HETEROARYLCARBOXYLIC ACID AMIDES | Bayer HealthCare AG (DE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003055878-A1 | 2-HETEROARYLCARBOXYLIC ACID AMIDES | BAYER HEALTHCARE AG (DE) | 2003-07-10 | — | — | WO | disclosed |