Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL11033987 | 0.88 | ALDH1A1 (0.54) | ALDH1A1TSHRTP53TDP1HDAC8 | |
| Styrene SCHEMBL6811672 | 0.86 | ALDH1A1 (0.64) | ALDH1A1TSHRTP53TDP1HDAC8 | |
| Styrene SCHEMBL10628603 | 0.86 | ALDH1A1 (0.52) | ALDH1A1TSHRTP53TDP1MEN1 | |
| Styrene SCHEMBL28211071 | 0.85 | ALDH1A1 (0.78) | ALDH1A1TSHRTP53TDP1CYP2A6 | |
| Styrene SCHEMBL93585 | 0.83 | ALDH1A1 (0.74) | ALDH1A1TSHRTP53TDP1CYP2A6 | |
| Styrene SCHEMBL290213 | 0.83 | ALDH1A1 (0.74) | ALDH1A1TSHRTP53TDP1CYP2A6 | |
| Styrene SCHEMBL8063766 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TSHRTP53TDP1CYP2A6 | |
| Styrene SCHEMBL27304453 | 0.82 | ALDH1A1 (0.64) | ALDH1A1TSHRTP53TDP1CYP2A6 | |
| Styrene SCHEMBL2233731 | 0.81 | ALDH1A1 (0.70) | ALDH1A1TSHRTP53TDP1CYP2A6 | |
| Styrene SCHEMBL8848519 | 0.81 | ALDH1A1 (0.70) | ALDH1A1TSHRTP53TDP1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192959-B1 | Antithrombotic surface treating agent and medical apparatus | TERUMO CORP (JP) | 2018-02-14 | — | — | EP | claimed |
| US-20160039964-A1 | WELL DEFINED, HIGHLY CROSSLINKED NANOPARTICLES AND METHOD FOR MAKING SAME | BRIDGESTONE CORPORATION (JP) | 2016-02-11 | — | — | US | claimed |
| US-20110172364-A1 | Charged Nanoparticles And Method Of Controlling Charge | YAOHONG CHEN | 2011-07-14 | — | — | US | claimed |
| US-20070056900-A1 | Use of copolymers containing n-vinyl lactam for producing functionalized membranes | BASF AKTIENGESELLSCHAFT (DE) | 2007-03-15 | — | — | US | claimed |
| US-20050148748-A1 | Copolymers and blood filter using the same | TERUMO KABUSHIKI KAISHA (JP) | 2005-07-07 | — | — | US | claimed |
| US-20020064558-A1 | Antithrombotic surface treating agent and medical apparatus | TERUMO KABUSHIKI KAISHA (JP) | 2002-05-30 | — | — | US | claimed |
| EP-1192959-A2 | Antithrombotic surface treating agent and medical apparatus | TERUMO KABUSHIKI KAISHA (JP) | 2002-04-03 | — | — | EP | claimed |
| US-20020000403-A1 | Copolymers and blood filter using the same | TERUMO KABUSHIKI KAISHA (JP) | 2002-01-03 | — | — | US | claimed |
| EP-1156067-A2 | (Meth)Acrylic Copolymers comprising glycolether and aminoalkyl units and blood filter using the same | TERUMO KABUSHIKI KAISHA (JP) | 2001-11-21 | — | — | EP | claimed |
| US-4894409-A | BLEND OR AMINO GROUP CONTAINING DIENE POLYMER AND SILICA FILLER NONCRACKING, WEAR RESISTANCE | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1990-01-16 | — | — | US | claimed |
| EP-4347710-B1 | MIXER SYSTEM FOR PRODUCING AQUEOUS COATING MATERIALS | BASF COATINGS GMBH (DE) | 2026-05-13 | — | — | EP | disclosed |
| US-20250230323-A1 | ENCAPSULATED CORROSION INHIBITORS | CHEMETALL GMBH (DE) | 2025-07-17 | — | — | US | disclosed |
| EP-4514905-A1 | ENCAPSULATED CORROSION INHIBITORS | Chemetall GmbH (DE) | 2025-03-05 | — | — | EP | disclosed |
| EP-4514906-A1 | AQUEOUS COMPOSITIONS CONTAINING ENCAPSULATED CORROSION INHIBITORS AND METHOD MAKING USE THEREOF | Chemetall GmbH (DE) | 2025-03-05 | — | — | EP | disclosed |
| WO-2024181265-A1 | RESIN PARTICLES FOR CREATING PORES IN POLYIMIDE POROUS MEMBRANE, AND METHOD FOR PRODUCING SAME | 綜研化学株式会社 | 2024-09-06 | — | — | WO | disclosed |
| EP-0561379-A1 | Filter medium having a limited surface negative charge for treating a blood material | ASAHI MEDICAL Co., Ltd. (JP) | 1993-09-22 | — | — | EP | disclosed |
| WO-1993002383-A1 | NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-02-04 | — | — | WO | disclosed |
| US-4894409-A | BLEND OR AMINO GROUP CONTAINING DIENE POLYMER AND SILICA FILLER NONCRACKING, WEAR RESISTANCE | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1990-01-16 | — | — | US | disclosed |
| US-4761358-A | Electrostatographic encapsulated toner | FUJI PHOTO FILM CO., LTD. (JP) | 1988-08-02 | — | — | US | disclosed |
| US-4734351-A | DISPERSION OF POLYMER | FUJI PHOTO FILM CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020064558-A1 | Antithrombotic surface treating agent and medical apparatus | ITGA1, F2, F12 | ALDH1A1 352/4885TSHR 1144/4885TP53 3758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.