Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.53 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30955451 | 0.85 | PARP1 (0.57) | PARP1MEP1BF10ADRA1DFOLH1 | |
| SCHEMBL185773 | 0.85 | PARP1 (0.57) | PARP1MEP1BF10ADRA1DFOLH1 | |
| SCHEMBL10189495 | 0.83 | PARP1 (0.56) | PARP1MEP1BFOLH1OPRM1OPRD1 | |
| SCHEMBL8342426 | 0.83 | TAAR1 (0.55) | PARP1MEP1BFOLH1 | |
| SCHEMBL3054119 | 0.83 | CYP4F2 (0.62) | PARP1MEP1BF10FOLH1IDH1 | |
| SCHEMBL27649226 | 0.83 | FOLH1 (0.61) | MEP1BFOLH1MRGPRX4 | |
| SCHEMBL5207992 | 0.83 | CYP4F2 (0.45) | FOLH1MRGPRX4CYP4F2CYP4A11TSHR | |
| SCHEMBL11217303 | 0.82 | ALDH1A1 (0.56) | CYP4F2CYP4A11MAPTL3MBTL1 | |
| SCHEMBL31487553 | 0.81 | PARP1 (0.53) | PARP1MEP1BFOLH1IDH1CYP4F2 | |
| SCHEMBL5645749 | 0.81 | PARP1 (0.53) | PARP1MEP1BF10ADRA1DFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869055-A1 | NOVEL 5,7-DISUBSTITUTED Ý1,3¨THIAZOLOÝ4,5-D¨PYRIMIDIN-2(3H)-ONE DERIVATIVES | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| EP-1869056-A1 | NOVEL 5-SUBSTITUTED 7-AMINO-Ý1,3¨THIAZOLOÝ4,5-D¨PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006107258-A1 | NOVEL 5-SUBSTITUTED 7-AMINO-[1,3]THIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |
| WO-2006107257-A1 | NOVEL 5,7-DISUBSTITUTED [1,3]THIAZOLO[4,5-D]PYRIMIDIN-2(3H)-ONE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |