Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237603 | 0.87 | TSHR (0.46) | DPP4HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL5236953 | 0.84 | DPP4 (0.50) | DPP4HCRTR1HCRTR2 | |
| SCHEMBL5235073 | 0.83 | CHRNB2 (0.53) | DPP4ALDH1A1 | |
| SCHEMBL5235823 | 0.79 | CHRM2 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL4691220 | 0.78 | DPP4 (0.50) | DPP4PTK2HCRTR1HCRTR2GRM5 | |
| SCHEMBL5237860 | 0.77 | CCL5 (0.43) | — | |
| SCHEMBL5235643 | 0.77 | CHRNB2 (0.53) | ALDH1A1HPGDALOX15 | |
| SCHEMBL5237787 | 0.77 | DPP4 (0.49) | DPP4ALDH1A1HPGD | |
| SCHEMBL5234640 | 0.76 | HCRTR1 (0.52) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL5232470 | 0.75 | CCR5 (0.54) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |