SCHEMBL5233534

SCHEMBL5233534

CC(C)(C)OC(=O)NC1(C2CC(=O)N(Cc3ccccc3)C2)CC(=O)C1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
TSHR P16473 2/20 0.44
MAPK1 P28482 1/20 0.44
KMT2A Q03164 3/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
HPGD P15428 1/20 0.42
OPRM1 P35372 1/20 0.42
OPRD1 P41143 1/20 0.42
LMNA P02545 2/20 0.41
NPC1 O15118 1/20 0.41
GLA P06280 1/20 0.41
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.41
HTT P42858 1/20 0.40
PDE4A P27815 1/20 0.39
PDE4B Q07343 1/20 0.39
PDE4C Q08493 1/20 0.39
PDE4D Q08499 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4671695 0.90 KMT2A (0.45) ALDH1A1TSHRMAPK1KMT2ASMN1; SMN2
SCHEMBL5232248 0.89 ALDH1A1 (0.43) ALDH1A1TSHRMAPK1KMT2ASMN1; SMN2
SCHEMBL5238965 0.89 ALDH1A1 (0.43) ALDH1A1TSHRMAPK1KMT2ASMN1; SMN2
SCHEMBL5236800 0.88 ALDH1A1 (0.43) ALDH1A1TSHRMAPK1KMT2ASMN1; SMN2
SCHEMBL5233429 0.85 ALDH1A1 (0.41) ALDH1A1TSHRMAPK1KMT2ASMN1; SMN2
SCHEMBL6167072 0.77 ALDH1A1 (0.44) ALDH1A1TSHRMAPK1KMT2ASMN1; SMN2
SCHEMBL5235899 0.77 KMT2A (0.41) ALDH1A1TSHRMAPK1KMT2AL3MBTL1
SCHEMBL6865331 0.77 KMT2A (0.60) ALDH1A1TSHRMAPK1KMT2ASMN1; SMN2
SCHEMBL5425216 0.77 KMT2A (0.60) ALDH1A1TSHRMAPK1KMT2ASMN1; SMN2
SCHEMBL9185202 0.74 KMT2A (0.46) ALDH1A1KMT2AL3MBTL1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0990654-B1 SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVES DAIICHI SANKYO CO LTD (JP) 2007-11-14 EP disclosed
US-6448266-B1 COMPOUNDS SUCH AS 2-AMINO-7-(3-(3-AMINO-1-FLUOROCYCLOBUTAN-3-YL)PYRROLIDIN-1-YL)-6-FLUORO-1-(2-FLUORO-1-CYCLOPROPYL)-8-METHYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS, PNEUMOCOCCUS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-09-10 US disclosed
EP-0990654-A1 SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-04-05 EP disclosed