Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235359 | 0.86 | MAPT (0.58) | MAPTMAPK1HTTLMNAGAA | |
| SCHEMBL5232444 | 0.84 | HTT (0.52) | MAPTMAPK1HTTLMNAGAA | |
| SCHEMBL5236929 | 0.84 | MAPT (0.73) | MAPTMAPK1HTTLMNAGAA | |
| SCHEMBL594620 | 0.82 | MAPT (0.53) | MAPTMAPK1HTTLMNAGAA | |
| SCHEMBL5233900 | 0.82 | ALDH1A1 (0.55) | MAPTMAPK1HTTLMNAGAA | |
| SCHEMBL5232354 | 0.82 | FAAH (0.61) | MAPTMAPK1HTTLMNAGAA | |
| SCHEMBL5239407 | 0.82 | MAPT (0.52) | MAPTMAPK1HTTLMNAGAA | |
| SCHEMBL5232961 | 0.81 | SMN1; SMN2 (0.60) | MAPTHTTLMNAGAAALDH1A1 | |
| SCHEMBL5237873 | 0.81 | ALDH1A1 (0.58) | MAPTMAPK1HTTKDM4EALDH1A1 | |
| SCHEMBL10144139 | 0.81 | MAPT (0.67) | MAPTMAPK1HTTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |