Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233512 | 0.92 | MAPT (0.51) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5238583 | 0.89 | HSD17B10 (0.57) | MAPTSMN1; SMN2MEN1KMT2ACYP3A4 | |
| SCHEMBL5235359 | 0.88 | MAPT (0.58) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL594620 | 0.86 | MAPT (0.53) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5239940 | 0.86 | HIF1A (0.52) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5232354 | 0.86 | FAAH (0.61) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5233900 | 0.86 | ALDH1A1 (0.55) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5237873 | 0.86 | ALDH1A1 (0.58) | MAPTKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5232444 | 0.86 | HTT (0.52) | MAPTLMNAGAAKDM4EMAPK1 | |
| SCHEMBL5234202 | 0.85 | L3MBTL1 (0.68) | MAPTLMNAGAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |