Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237894 | 0.93 | SIGMAR1 (0.46) | SIGMAR1SMN1; SMN2MEN1USP2KMT2A | |
| SCHEMBL5236341 | 0.92 | ALDH1A1 (0.44) | SIGMAR1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5237863 | 0.90 | SIGMAR1 (0.41) | SIGMAR1HCRTR1HCRTR2L3MBTL1MAPK8 | |
| SCHEMBL5238559 | 0.87 | SIGMAR1 (0.40) | SIGMAR1KMT2AHCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL5236149 | 0.87 | MAPK1 (0.40) | SIGMAR1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL5238729 | 0.86 | EPHX2 (0.41) | SIGMAR1SMN1; SMN2HCRTR1HCRTR2NPC1 | |
| SCHEMBL5234742 | 0.86 | HCRTR1 (0.40) | SIGMAR1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL5236854 | 0.86 | HPGD (0.43) | SIGMAR1SMN1; SMN2MEN1KMT2AHCRTR1 | |
| SCHEMBL5233648 | 0.85 | HCRTR1 (0.42) | SIGMAR1SMN1; SMN2HCRTR1HCRTR2MAPK8 | |
| SCHEMBL5232680 | 0.85 | EPHX2 (0.40) | SIGMAR1SMN1; SMN2HCRTR1HCRTR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |