Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1488545 | 0.84 | NPSR1 (0.41) | NPSR1GPR55ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL4841029 | 0.83 | NPSR1 (0.45) | NPSR1GPR55ALDH1A1MAPTHTT | |
| SCHEMBL4837814 | 0.82 | NPSR1 (0.44) | NPSR1GPR55ALDH1A1MAPTHTT | |
| SCHEMBL8941983 | 0.78 | NPSR1 (0.50) | NPSR1GPR55ALDH1A1MAPTHTT | |
| SCHEMBL5457749 | 0.77 | NPSR1 (0.45) | NPSR1GPR55CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL5455644 | 0.74 | NPSR1 (0.53) | NPSR1GPR55CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL9230657 | 0.73 | CTSL (0.49) | ALDH1A1CYP2D6CYP3A4CYP2C9USP2 | |
| SCHEMBL20993041 | 0.73 | CHRM2 (0.43) | NPSR1GPR55ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL4840431 | 0.72 | NPSR1 (0.46) | NPSR1GPR55CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL4840944 | 0.71 | CYP3A4 (0.46) | NPSR1GPR55ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100478343-C | Purine compound and use as cannabinoid receptor ligands | PFIZER (US) | 2009-04-15 | — | — | CN | disclosed |
| CN-100439369-C | Purine compounds and their use as cannabinoid receptor ligands | PFIZER (US) | 2008-12-03 | — | — | CN | disclosed |
| EP-1558615-B8 | PURINE COMPOUNDS AND USE THEREOF AS CANNABINOID RECEPTOR LIGANDS | PFIZER PROD INC (US) | 2007-10-10 | — | — | EP | disclosed |
| EP-1558615-B1 | PURINE COMPOUNDS AND USE THEREOF AS CANNABINOID RECEPTOR LIGANDS | PFIZER PROD INC (US) | 2007-08-29 | — | — | EP | disclosed |
| EP-1558615-B1 | PURINE COMPOUNDS AND USE THEREOF AS CANNABINOID RECEPTOR LIGANDS | PFIZER PROD INC (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20070123507-A1 | Process for converting heterocyclic ketones to amido-substituted heterocycles | PFIZER INC. | 2007-05-31 | — | — | US | disclosed |
| US-20070123507-A1 | Process for converting heterocyclic ketones to amido-substituted heterocycles | PFIZER INC. | 2007-05-31 | — | — | US | disclosed |
| US-20070123507-A1 | Process for converting heterocyclic ketones to amido-substituted heterocycles | PFIZER INC. | 2007-05-31 | — | — | US | disclosed |
| CN-1955182-A | Purine compound and use as cannabinoid receptor ligands | PFIZER (US) | 2007-05-02 | — | — | CN | disclosed |
| CN-1955181-A | Purine compound and use as cannabinoid receptor ligands | PFIZER (US) | 2007-05-02 | — | — | CN | disclosed |
| US-20060241120-A1 | Cannabinoid Receptor Ligands and Uses Thereof | PFIZER INC | 2006-10-26 | — | — | US | disclosed |
| EP-1692103-A1 | PROCESS FOR CONVERTING HETEROCYCLIC KETONES TO AMIDO-SUBSTITUTED HETEROCYCLES | Pfizer Products Inc. (US) | 2006-08-23 | — | — | EP | disclosed |
| EP-1638570-A1 | PYRIMIDINE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS | Pfizer Products Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| CN-1708499-A | Purine compounds and their use as cannabinoid receptor ligands | PFIZER (US) | 2005-12-14 | — | — | CN | disclosed |
| EP-1558615-A1 | PURINE COMPOUNDS AND USE THEREOF AS CANNABINOID RECEPTOR LIGANDS | Pfizer Products Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2005054184-A1 | PROCESS FOR CONVERTING HETEROCYCLIC KETONES TO AMIDO-SUBSTITUTED HETEROCYCLES | PFIZER PRODUCTS INC. (US) | 2005-06-16 | — | — | WO | disclosed |
| US-20040259887-A1 | Cannabinoid receptor ligands and uses thereof | PFIZER INC | 2004-12-23 | — | — | US | disclosed |
| WO-2004110453-A1 | PYRIMIDINE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS | PFIZER PRODUCTS INC. (US) | 2004-12-23 | — | — | WO | disclosed |
| US-20040092520-A1 | Purine compounds and uses thereof | PFIZER INC. | 2004-05-13 | — | — | US | disclosed |
| WO-2004037823-A1 | PURINE COMPOUNDS AND USES THEREOF AS CANNABINOID RECEPTOR LIGANDS | PFIZER PRODUCTS INC. (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241120-A1 | Cannabinoid Receptor Ligands and Uses Thereof | CNR1, CNR2, GPR18 | NPSR1 13/4885GPR55 10/4885ALDH1A1 1926/4885 |
| US-20040259887-A1 | Cannabinoid receptor ligands and uses thereof | CNR1, CNR2, GPR18 | NPSR1 10/4885GPR55 12/4885ALDH1A1 1683/4885 |
| US-20070123507-A1 | Process for converting heterocyclic ketones to amido-substituted heterocycles | AKR1C2, AKR1C1, AKR1C4 | NPSR1 2608/4885GPR55 4172/4885ALDH1A1 291/4885 |
| US-20040092520-A1 | Purine compounds and uses thereof | CNR1, CNR2, P2RY1 | NPSR1 30/4885GPR55 59/4885ALDH1A1 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.