Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235809 | 0.91 | MAPT (0.44) | ADAMTS5MMP2KDM4EALDH1A1MAPT | |
| SCHEMBL5239098 | 0.87 | MEN1 (0.39) | ADAMTS5ALDH1A1MAPTKMT2A | |
| SCHEMBL5236743 | 0.86 | ALDH1A1 (0.45) | KDM4EALDH1A1MAPTMGLLKMT2A | |
| SCHEMBL5231422 | 0.85 | NOTUM (0.46) | MAPTPHGDHKMT2A | |
| SCHEMBL5232294 | 0.85 | ALDH1A1 (0.39) | KDM4EALDH1A1MAPTCA1CA2 | |
| SCHEMBL5235446 | 0.84 | ALDH1A1 (0.37) | ADAMTS5ALDH1A1MAPTKMT2A | |
| SCHEMBL5232239 | 0.83 | SCD (0.38) | ADAMTS5MMP2SCN9AKDM4EALDH1A1 | |
| SCHEMBL5233364 | 0.83 | MAPT (0.39) | SCN9AALDH1A1MAPTKMT2A | |
| SCHEMBL5234847 | 0.82 | KMT2A (0.40) | KDM4EALDH1A1MAPTCA1CA2 | |
| SCHEMBL5238192 | 0.81 | CYP2C19 (0.37) | ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |