Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236419 | 0.91 | ADAMTS5 (0.39) | MAPTKMT2AALDH1A1KDM4EMMP2 | |
| SCHEMBL5231422 | 0.88 | NOTUM (0.46) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5239098 | 0.88 | MEN1 (0.39) | MAPTSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL5236743 | 0.87 | ALDH1A1 (0.45) | MAPTSMN1; SMN2RAB9AHTTMAPK1 | |
| SCHEMBL5233364 | 0.86 | MAPT (0.39) | MAPTRAB9AHTTKMT2AALDH1A1 | |
| SCHEMBL5235446 | 0.85 | ALDH1A1 (0.37) | MAPTSMN1; SMN2HTTMAPK1MEN1 | |
| SCHEMBL5238192 | 0.84 | CYP2C19 (0.37) | MAPTRAB9AHTTMAPK1MEN1 | |
| SCHEMBL5232294 | 0.83 | ALDH1A1 (0.39) | MAPTSMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL5234716 | 0.83 | ALDH1A1 (0.43) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL5237871 | 0.82 | DRD2 (0.40) | MAPTALDH1A1NOTUMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |