Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 19/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310333 | 0.89 | CCR2 (0.52) | CCR2KCNH2GPR139 | |
| SCHEMBL5241551 | 0.88 | CCR2 (0.61) | CCR2KCNH2GPR139 | |
| SCHEMBL5240139 | 0.87 | GPR139 (0.46) | CCR2KCNH2GPR139 | |
| SCHEMBL5239532 | 0.85 | CCR2 (0.49) | CCR2KCNH2GPR139 | |
| SCHEMBL5235055 | 0.85 | CCR2 (0.51) | CCR2KCNH2GPR139 | |
| SCHEMBL5311807 | 0.84 | CCR2 (0.50) | CCR2KCNH2 | |
| SCHEMBL5321602 | 0.84 | CCR2 (0.49) | CCR2KCNH2GPR139 | |
| SCHEMBL5313796 | 0.83 | CCR2 (0.53) | CCR2KCNH2GPR139 | |
| SCHEMBL5234857 | 0.82 | CCR2 (0.52) | CCR2KCNH2 | |
| SCHEMBL5308687 | 0.82 | CCR2 (0.45) | CCR2KCNH2GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565436-A4 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2007-07-18 | — | — | EP | disclosed |
| EP-1565436-A2 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004050024-A2 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2004-06-17 | — | — | WO | disclosed |