Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235429 | 0.82 | ALDH1A1 (0.44) | TGFBR1KDM4EALDH1A1PDE4DL3MBTL1 | |
| SCHEMBL4865701 | 0.78 | EGFR (0.55) | TGFBR1KDM4EALDH1A1PDE4DCA12 | |
| SCHEMBL5234607 | 0.78 | TGFBR1 (0.43) | TGFBR1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL4868672 | 0.71 | TGFBR1 (0.49) | TGFBR1KDM4EALDH1A1L3MBTL1CYP1A2 | |
| SCHEMBL5232777 | 0.70 | TGFBR1 (0.46) | TGFBR1KDM4EALDH1A1L3MBTL1CYP1A2 | |
| SCHEMBL5236967 | 0.68 | TGFBR1 (0.55) | TGFBR1THRB | |
| SCHEMBL5231391 | 0.68 | EGFR (0.53) | TGFBR1KDM4EALDH1A1PDE4DCA12 | |
| SCHEMBL5231066 | 0.68 | TGFBR1 (0.41) | TGFBR1CYP1A2 | |
| SCHEMBL28467069 | 0.66 | PDE4D (0.45) | KDM4EALDH1A1PDE4DCA12CA1 | |
| SCHEMBL38663185 | 0.65 | PDE4D (0.53) | KDM4EALDH1A1PDE4DCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |