Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237613 | 0.90 | CACNA1H (0.46) | EGLN1SMN1; SMN2KDM4EHTTHSD17B10 | |
| SCHEMBL5236004 | 0.86 | SMN1; SMN2 (0.52) | WNT3ASMN1; SMN2KDM4EHTTHSD17B10 | |
| SCHEMBL5240826 | 0.84 | EGLN1 (0.43) | EGLN1SMN1; SMN2KDM4EHTTHSD17B10 | |
| SCHEMBL14341174 | 0.84 | WNT3A (0.51) | WNT3ASMN1; SMN2KDM4EHTTHSD17B10 | |
| SCHEMBL5241403 | 0.83 | FAAH (0.48) | SMN1; SMN2KDM4ELMNAHPGDNPSR1 | |
| SCHEMBL5237599 | 0.83 | EGLN1 (0.55) | WNT3AEGLN1SMN1; SMN2KDM4EHTT | |
| SCHEMBL5236980 | 0.82 | L3MBTL1 (0.50) | SMN1; SMN2KDM4EHTTLMNAMAPK1 | |
| SCHEMBL593375 | 0.82 | SMN1; SMN2 (0.56) | WNT3ASMN1; SMN2KDM4EHTTHSD17B10 | |
| SCHEMBL593717 | 0.81 | SMN1; SMN2 (0.48) | WNT3ASMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL5237004 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4EHTTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |