Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236322 | 0.89 | EGLN1 (0.54) | EGLN1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL5238882 | 0.83 | EGLN1 (0.51) | EGLN1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL5240826 | 0.82 | EGLN1 (0.43) | EGLN1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL5237599 | 0.81 | EGLN1 (0.55) | EGLN1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL5231436 | 0.79 | CNR2 (0.51) | EGLN1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL3442393 | 0.78 | MGLL (0.58) | ALDH1A1TSHRHTTKMT2ACKS1B | |
| SCHEMBL31589961 | 0.77 | EGLN1 (0.55) | EGLN1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL5237235 | 0.76 | MGLL (0.53) | EGLN1KDM4ERAB9APOLBCNR2 | |
| SCHEMBL5236952 | 0.76 | EGLN1 (0.46) | EGLN1KMT2ANPC1RAB9ACNR2 | |
| SCHEMBL5238721 | 0.76 | MCHR1 (0.50) | CYP2C9CYP2C19CNR2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |