Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238842 | 0.86 | EGLN1 (0.43) | EGLN1KMT2AMCHR1CNR1 | |
| SCHEMBL5236962 | 0.82 | EGLN1 (0.45) | EGLN1NPY5RPDE10AAAK1ITGA4 | |
| SCHEMBL5234753 | 0.82 | DGAT1 (0.41) | EGLN1RAB9AKCNH2MCHR1CNR1 | |
| SCHEMBL5237002 | 0.81 | DGAT1 (0.41) | KCNH2MCHR1CNR1CNR2 | |
| SCHEMBL5237578 | 0.80 | KDM4E (0.43) | KMT2AKCNH2CNR2 | |
| SCHEMBL5233791 | 0.80 | PANK3 (0.41) | NPC1RAB9AKMT2A | |
| SCHEMBL5236765 | 0.79 | CACNA1G (0.39) | MCHR1 | |
| SCHEMBL5233010 | 0.78 | MGLL (0.44) | KCNH2 | |
| SCHEMBL5236322 | 0.76 | EGLN1 (0.54) | EGLN1PDE10AKMT2AKCNH2CNR1 | |
| SCHEMBL5237336 | 0.76 | EGLN1 (0.54) | EGLN1NPC1RAB9AKMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |