Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12172203 | 0.88 | TRPM8 (0.52) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL980974 | 0.86 | PRKCZ (0.53) | MAPTNPC1RAB9ASMN1; SMN2PRKCZ | |
| SCHEMBL938199 | 0.85 | HPGD (0.55) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL939732 | 0.84 | ALDH1A1 (0.52) | MAPK14GCGRALDH1A1HPGD | |
| SCHEMBL29383542 | 0.81 | MAPT (0.60) | MAPTNPC1RAB9ASMN1; SMN2PRKCZ | |
| SCHEMBL9454728 | 0.80 | HSD17B10 (0.53) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL980147 | 0.78 | CA12 (0.42) | MAPTNPC1RAB9ASMN1; SMN2PRKCZ | |
| SCHEMBL7365076 | 0.78 | KMT2A (0.69) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31704904 | 0.77 | CYP2C9 (0.47) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL31706596 | 0.77 | CYP2C9 (0.47) | MAPTNPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745051-A1 | THIENOPYRIDAZINES AS IKK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-24 | — | — | EP | disclosed |
| US-7135470-B2 | Thienopyridazines as IKK inhibitors | ROCHE PALO ALTO LLC (US) | 2006-11-14 | — | — | US | disclosed |
| US-20050272730-A1 | Thienopyridazines as IKK inhibitors | ROCHE PALO ALTO LLC | 2005-12-08 | — | — | US | disclosed |
| WO-2005105808-A1 | THIENOPYRIDAZINES AS IKK INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272730-A1 | Thienopyridazines as IKK inhibitors | IKBKE, IKBKB, NFKBIA | MAPT 3104/4885KDM4E 1039/4885NPC1 2505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.