Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234607 | 0.86 | TGFBR1 (0.43) | THRBPTGS2TGFBR1MAPK14KDR | |
| SCHEMBL23389877 | 0.82 | TGFBR1 (0.38) | TGFBR1 | |
| SCHEMBL5232936 | 0.82 | PTGS2 (0.46) | THRBPTGS2TGFBR1MAPK14KDR | |
| SCHEMBL29796672 | 0.82 | TGFBR1 (0.38) | TGFBR1 | |
| SCHEMBL5229013 | 0.81 | TGFBR1 (0.42) | TGFBR1KDM4EMEN1KMT2A | |
| SCHEMBL4864274 | 0.78 | MIF (0.45) | TGFBR1MEN1ALDH1A1KMT2A | |
| SCHEMBL4869716 | 0.77 | PTGS2 (0.53) | THRBPTGS2TGFBR1MAPK14KDR | |
| SCHEMBL23389792 | 0.70 | TGFBR1 (0.39) | TGFBR1MAPK14MEN1KMT2A | |
| SCHEMBL29796646 | 0.70 | TGFBR1 (0.39) | TGFBR1MAPK14MEN1KMT2A | |
| SCHEMBL5232777 | 0.70 | TGFBR1 (0.46) | TGFBR1KDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |