Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232777 | 0.87 | TGFBR1 (0.46) | TGFBR1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL23389877 | 0.84 | TGFBR1 (0.38) | TGFBR1 | |
| SCHEMBL29796672 | 0.84 | TGFBR1 (0.38) | TGFBR1 | |
| SCHEMBL4864274 | 0.83 | MIF (0.45) | TGFBR1GRM5TGFBR2MEN1KMT2A | |
| SCHEMBL5230843 | 0.81 | KDM4E (0.40) | TGFBR1KDM4EMEN1USP2MAPK1 | |
| SCHEMBL5237402 | 0.81 | THRB (0.43) | TGFBR1KDM4EMEN1KMT2A | |
| SCHEMBL4874607 | 0.78 | TGFBR1 (0.52) | TGFBR1 | |
| SCHEMBL5231066 | 0.75 | TGFBR1 (0.41) | TGFBR1DHODHGRM5TGFBR2MEN1 | |
| SCHEMBL3271808 | 0.73 | MIF (0.45) | TGFBR1TGFBR2MEN1KMT2A | |
| SCHEMBL29796646 | 0.72 | TGFBR1 (0.39) | TGFBR1GRM5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |