Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.54 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.50 |
| ▸ | F13A1 | P00488 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10591303 | 0.85 | KDM4E (0.66) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL955708 | 0.84 | ENPP2 (0.53) | LPLLIPGENPP2 | |
| SCHEMBL14756882 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL1010528 | 0.81 | TAAR1 (0.62) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL901531 | 0.80 | NQO2 (0.49) | LPLLIPGKDM4EENPP2 | |
| SCHEMBL2315033 | 0.80 | KDM4E (0.66) | LPLLIPGKDM4EALDH1A1LMNA | |
| SCHEMBL10112805 | 0.79 | HDAC3 (0.59) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL5632567 | 0.79 | SPR (0.66) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL13895358 | 0.79 | KDM4E (0.58) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL3065864 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833836-A1 | IMIDAZO-FUSED THIAZOLO [4,5-B] PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Brystol-Myers Squibb Company (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006053120-A1 | IMIDAZO-FUSED THIAZOLO[4,5-b]PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-18 | — | — | WO | disclosed |
| WO-2006053166-A1 | 8H-IMIDAZO[4,5-D]THIAZOLO[4,5-B]PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-18 | — | — | WO | disclosed |