Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 5/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233449 | 0.87 | CRBN (0.44) | CRBNAVPR2AVPR1AHPGDALDH1A1 | |
| SCHEMBL8820724 | 0.84 | AVPR2 (0.52) | CRBNAVPR2AVPR1ASTAT3HPGD | |
| SCHEMBL5237135 | 0.80 | AVPR2 (0.54) | AVPR2AVPR1AOXTR | |
| SCHEMBL5239551 | 0.77 | AVPR2 (0.67) | AVPR2AVPR1AALDH1A1 | |
| SCHEMBL7319146 | 0.77 | AVPR2 (0.48) | CRBNAVPR2AVPR1AOXTR | |
| SCHEMBL5320547 | 0.74 | AVPR2 (0.55) | CRBNAVPR2AVPR1A | |
| SCHEMBL5233013 | 0.73 | AVPR2 (0.64) | CRBNAVPR2AVPR1ASTAT3HPGD | |
| SCHEMBL7337254 | 0.73 | AVPR2 (0.52) | CRBNAVPR2AVPR1ASTAT3CYP11B2 | |
| SCHEMBL9065667 | 0.71 | AVPR2 (0.59) | AVPR2AVPR1AALDH1A1RAB9AKMT2A | |
| SCHEMBL7314107 | 0.71 | HPGD (0.44) | AVPR2AVPR1ASTAT3OXTRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |