Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237499 | 0.87 | CRBN (0.46) | CRBNHPGDALDH1A1AVPR2AVPR1A | |
| SCHEMBL7314107 | 0.85 | HPGD (0.44) | HPGDHTR2CALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5236789 | 0.79 | KMT2A (0.44) | HPGDALDH1A1MAPTL3MBTL1F12 | |
| SCHEMBL9059366 | 0.75 | AVPR2 (0.61) | HPGDALDH1A1MAPTL3MBTL1AVPR2 | |
| SCHEMBL7319146 | 0.74 | AVPR2 (0.48) | CRBNAVPR2AVPR1A | |
| SCHEMBL5232579 | 0.74 | MAPT (0.39) | CRBNHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5232572 | 0.74 | MAPT (0.39) | CRBNHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL20618356 | 0.72 | KCNJ1 (0.42) | CRBNHPGDALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7337254 | 0.70 | AVPR2 (0.52) | CRBNHPGDALDH1A1AVPR2AVPR1A | |
| SCHEMBL8820724 | 0.70 | AVPR2 (0.52) | CRBNHPGDALDH1A1L3MBTL1AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |