Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BHMT | Q93088 | 3/20 | 0.32 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Penicillamine SCHEMBL27615310 | 1.00 | ALDH1A1 (0.67) | ALDH1A1MAPTPTGS1LMNAPTGS2 | |
| Penicillamine SCHEMBL603349 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1LMNATDP1 | |
| Penicillamine SCHEMBL4343 | 0.82 | — | — | |
| Dl-Penicillamine SCHEMBL22322162 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1LMNATDP1 | |
| Penicillamine SCHEMBL129296 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1LMNATDP1 | |
| Dl-Penicillamine SCHEMBL57527 | 0.82 | — | — | |
| Dl-Penicillamine SCHEMBL159653 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1LMNATDP1 | |
| Dl-Penicillamine SCHEMBL4344 | 0.82 | — | — | |
| Penicillamine SCHEMBL2329725 | 0.80 | ALDH1A1 (0.78) | ALDH1A1MAPTPTGS1LMNASLC7A11 | |
| Dl-Penicillamine SCHEMBL2319399 | 0.80 | ALDH1A1 (0.78) | ALDH1A1MAPTPTGS1LMNASLC7A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799683-A1 | HEXAHYDRO-PYRAZINO[1,2-A]PYRIMIDINE-4, 7-DIONE DERIVATIVES SUBSTITUTED WITH AMINO ACIDS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006024390-A1 | HEXAHYDRO-PYRAZINO[1,2-A]PYRIMIDINE-4, 7-DIONE DERIVATIVES SUBSTITUTED WITH AMINO ACIDS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-03-09 | — | — | WO | disclosed |
| EP-1420826-A2 | COMBINATION PREPARATIONS OF ARYL SUBSTITUTED PROPANOLAMINE DERIVATIVES WITH OTHER ACTIVE INGREDIENTS AND THE USE THEREOF | Aventis Pharma Deutschland GmbH (DE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003018059-A2 | COMBINATION PREPARATIONS OF ARYL SUBSTITUTED PROPANOLAMINE DERIVATIVES WITH OTHER ACTIVE INGREDIENTS AND THE USE THEREOF | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-03-06 | — | — | WO | disclosed |
| EP-1117645-A1 | ARYL-SUBSTITUTED PROPANOLAMINE DERIVATIVES, METHODS FOR THEIR PRODUCTION, MEDICAMENTS CONTAINING SAID COMPOUNDS AND THEIR USE | Aventis Pharma Deutschland GmbH (DE) | 2001-07-25 | — | — | EP | disclosed |
| EP-1117676-A1 | PROPANOLAMINE DERIVATIVES LINKED WITH BILE ACID USED FOR TREATING DISORDERS OF THE LIPID METABOLISM | Aventis Pharma Deutschland GmbH (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000020437-A1 | PROPANOLAMINE DERIVATIVES LINKED WITH BILE ACID USED FOR TREATING DISORDERS OF THE LIPID METABOLISM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-04-13 | — | — | WO | disclosed |
| WO-2000020392-A1 | ARYL-SUBSTITUTED PROPANOLAMINE DERIVATIVES, METHODS FOR THEIR PRODUCTION, MEDICAMENTS CONTAINING SAID COMPOUNDS AND THEIR USE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-04-13 | — | — | WO | disclosed |