Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507293 | 0.77 | NOS3 (0.57) | KIF11ALDH1A1GAANOS3NOS2 | |
| SCHEMBL347025 | 0.76 | CCR1 (0.48) | KIF11ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL29373631 | 0.76 | CCR1 (0.48) | KIF11ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL29453375 | 0.76 | CCR1 (0.48) | KIF11ALDH1A1HPGDALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL23538061 | 0.74 | CCR1 (0.46) | KIF11ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL2783812 | 0.74 | CCR1 (0.46) | KIF11ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL278964 | 0.74 | LMNA (0.41) | KIF11ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL15663789 | 0.74 | CCR1 (0.46) | KIF11ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL335953 | 0.74 | CCR1 (0.46) | KIF11ALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL23459202 | 0.74 | CCR1 (0.46) | KIF11ALDH1A1HPGDALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379505-B1 | INHIBITION OF RAF KINASE USING QUINOLYL, ISOQUINOLYL OR PYRIDYL UREAS | BAYER PHARMACEUTICALS CORP (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1379507-A1 | HETEROARYL UREAS CONTAINING NITROGEN HETERO-ATOMS AS p38 KINASE INHIBITORS | Bayer Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002085859-A1 | HETEROARYL UREAS CONTAINING NITROGEN HETERO-ATOMS AS p38 KINASE INHIBITORS | BAYER CORPORATION (US) | 2002-10-31 | — | — | WO | disclosed |