Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 5/20 | 0.31 |
| ▸ | RAB9A | P51151 | 4/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.31 |
| ▸ | RELA | Q04206 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237769 | 1.00 | GRM5 (0.35) | GRM5ALKSLC22A12PREPALDH1A1 | |
| SCHEMBL5238502 | 0.93 | GRM5 (0.34) | GRM5SLC22A12ALDH1A1GAANPSR1 | |
| SCHEMBL5238497 | 0.93 | GRM5 (0.34) | GRM5SLC22A12ALDH1A1GAANPSR1 | |
| SCHEMBL5239805 | 0.89 | THRB (0.40) | ALDH1A1GAATGFBR1SMN1; SMN2LMNA | |
| SCHEMBL5239810 | 0.89 | THRB (0.40) | ALDH1A1GAATGFBR1SMN1; SMN2LMNA | |
| SCHEMBL5239257 | 0.88 | CYP1A2 (0.41) | ALDH1A1NPSR1TGFBR1RAB9ASMN1; SMN2 | |
| SCHEMBL5239266 | 0.88 | CYP1A2 (0.41) | ALDH1A1NPSR1TGFBR1RAB9ASMN1; SMN2 | |
| SCHEMBL4486620 | 0.87 | TGFBR1 (0.38) | SLC22A12PREPTGFBR1 | |
| SCHEMBL8336424 | 0.87 | TGFBR1 (0.38) | SLC22A12PREPTGFBR1 | |
| SCHEMBL4486616 | 0.87 | TGFBR1 (0.38) | SLC22A12PREPTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |