Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239810 | 1.00 | THRB (0.40) | THRBTGFBR1MAPK14PKMALOX15 | |
| SCHEMBL5237774 | 0.89 | GRM5 (0.35) | TGFBR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5237769 | 0.89 | GRM5 (0.35) | TGFBR1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5239257 | 0.88 | CYP1A2 (0.41) | THRBTGFBR1MAPK14HSD17B10ALDH1A1 | |
| SCHEMBL5239266 | 0.88 | CYP1A2 (0.41) | THRBTGFBR1MAPK14HSD17B10ALDH1A1 | |
| SCHEMBL5231673 | 0.87 | THRB (0.43) | THRBTGFBR1MAPK14PKMALOX15 | |
| SCHEMBL5231678 | 0.87 | THRB (0.43) | THRBTGFBR1MAPK14PKMALOX15 | |
| SCHEMBL5238643 | 0.86 | CYP1A2 (0.38) | ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL5238650 | 0.86 | CYP1A2 (0.38) | ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL5236211 | 0.86 | GRM5 (0.37) | TGFBR1HSD17B10MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |