Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 4/20 | 0.86 |
| ▸ | HTR3A | P46098 | 3/20 | 0.86 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.86 |
| ▸ | HTR3B | O95264 | 2/20 | 0.86 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.86 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.86 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.86 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.66 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | HTR1D | P28221 | 2/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 4/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2410870 | 0.93 | ADRB1 (1.00) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL234280 | 0.93 | ADRB1 (1.00) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| Bromide SCHEMBL11070661 | 0.91 | ADRB1 (0.96) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| Hydrochloric Acid SCHEMBL2302729 | 0.91 | ADRB1 (0.96) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| Hydrochloric Acid SCHEMBL1724680 | 0.91 | ADRB1 (0.96) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| Piperazine SCHEMBL8590918 | 0.91 | ADRB1 (0.96) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9058690 | 0.88 | ADRB1 (0.89) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL2881283 | 0.88 | ADRB1 (0.89) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5686228 | 0.86 | ADRB1 (0.86) | ADRB1HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7171062 | 0.86 | ADRB1 (0.86) | ADRB1HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130005710-A1 | AMINOPYRIDINE DERIVATIVE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-01-03 | — | — | US | disclosed |
| EP-2502909-A1 | AMINOPYRIDINE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-09-26 | — | — | EP | disclosed |
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| US-20070219234-A1 | Thienopyridine Derivatives | SANKYO COMPANY, LIMITED (JP) | 2007-09-20 | — | — | US | disclosed |
| EP-1764367-A1 | THIENOPYRIDINE DERIVATIVES | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005710-A1 | AMINOPYRIDINE DERIVATIVE | DCX, NR0B1, NR4A1 | ADRB1 126/4885HTR3A 432/4885HTR3E 1569/4885 |
| US-20070219234-A1 | Thienopyridine Derivatives | RASGRP1, NRAS, HRH3 | ADRB1 241/4885HTR3A 3772/4885HTR3E 4205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.