Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.86 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.70 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.70 |
| ▸ | HTR3A | P46098 | 4/20 | 0.64 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.64 |
| ▸ | HTR3B | O95264 | 2/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | HTR1D | P28221 | 2/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443521 | 0.93 | ADRB1 (1.00) | ADRB1CHRNB2CHRNA4HTR3AHTR3E | |
| Hydrochloric Acid SCHEMBL18577062 | 0.91 | ADRB1 (0.96) | ADRB1CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL5237992 | 0.86 | ADRB1 (0.86) | ADRB1CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL4526848 | 0.85 | ADRB1 (0.88) | ADRB1CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL5664269 | 0.83 | CHRNB2 (1.00) | ADRB1CHRNB2CHRNA4 | |
| SCHEMBL2873315 | 0.83 | ADRB1 (0.80) | ADRB1CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL4925469 | 0.81 | ADRB1 (0.77) | ADRB1CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL8891314 | 0.81 | ADRB1 (0.77) | ADRB1CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL5682967 | 0.81 | ADRB1 (0.77) | ADRB1CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL11922738 | 0.81 | ADRB1 (0.66) | ADRB1CHRNB2CHRNA4HTR3AHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1645556-A1 | Arylpiperazine-benzoylamide derivatives useful as pharmaceutical agents | Boehringer Ingelheim International GmbH (DE) | 2006-04-12 | — | — | EP | disclosed |