Sugi Predict

Sugi Predict / Compounds / SCHEMBL5238486

SCHEMBL5238486

SCHEMBL5238486

COc1ccc(N)c(OC)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 1/20 0.45
▸ EP300 Q09472 1/20 0.44
▸ KAT8 Q9H7Z6 1/20 0.44
▸ ALDH1A1 P00352 6/20 0.43
▸ CYP3A4 P08684 3/20 0.43
▸ TDP1 Q9NUW8 3/20 0.43
▸ TSHR P16473 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43
▸ GAA P10253 2/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ ADRA2B P18089 1/20 0.41
▸ PTGS1 P23219 1/20 0.41
▸ TUBB4A P04350 3/20 0.41
▸ TUBB P07437 3/20 0.41
▸ TUBA3C P0DPH7 3/20 0.41
▸ TUBA1B P68363 3/20 0.41
▸ TUBA4A P68366 3/20 0.41
▸ TUBB4B P68371 3/20 0.41
▸ TUBB3 Q13509 3/20 0.41
▸ TUBB2A Q13885 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7937909 0.83 TUBB1 (0.41) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL11073801 0.83 IDO1 (0.45) IDO1EP300KAT8ALDH1A1CYP3A4
SCHEMBL9672377 0.82 IDO1 (0.48) IDO1EP300KAT8ALDH1A1CYP3A4
SCHEMBL34473712 0.81 IDO1 (0.34) IDO1EP300KAT8ALDH1A1CYP3A4
SCHEMBL10944142 0.80 TUBB4A (0.42) IDO1ALDH1A1CYP3A4TDP1TSHR
SCHEMBL30126262 0.80 TUBB4A (0.42) IDO1ALDH1A1CYP3A4TDP1TSHR
SCHEMBL2426464 0.80 ALDH1A1 (0.39) IDO1ALDH1A1CYP3A4TDP1TSHR
SCHEMBL1122902 0.79 IDO1 (0.50) IDO1EP300KAT8ALDH1A1CYP3A4
SCHEMBL24824751 0.78 CYP3A4 (0.40) IDO1ALDH1A1CYP3A4TDP1TSHR
Hydrochloric Acid SCHEMBL6667575 0.77 EP300 (0.52) IDO1EP300KAT8ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2002537397-A — — 2002-11-05 — — JP claimed
EP-1157026-A1 POLYCYCLO HETEROCYCLIC DERIVATIVES AS ANTIINFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2001-11-28 — — EP claimed
US-6242453-B1 Polycyclo heterocyclic derivatives as antiinflammatory agents BOEHRINGER INGELHEIM PHARMACEUTICALS, INC 2001-06-05 — — US claimed
WO-2000050425-A1 POLYCYCLO HETEROCYCLIC DERIVATIVES AS ANTIINFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-08-31 — — WO claimed
US-20210002230-A1 OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE Stingthera, Inc. 2021-01-07 — — US disclosed
US-10745358-B2 Oxoacridinyl acetic acid derivatives and methods of use SILICON SWAT, INC. (US) 2020-08-18 — — US disclosed
US-20190161449-A1 OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE SILICON SWAT, INC. 2019-05-30 — — US disclosed
CN-101238131-A Bridged piperazine and piperidine derivatives as CCR1 antagonists NOVARTIS AG (CH) 2008-08-06 — — CN disclosed
US-20070196270-A1 Compounds As Ccri Antagonists HENG RICHARD 2007-08-23 — — US disclosed
US-20070196270-A1 Compounds As Ccri Antagonists HENG RICHARD 2007-08-23 — — US disclosed
US-20070196270-A1 Compounds As Ccri Antagonists HENG RICHARD 2007-08-23 — — US disclosed
EP-1794164-A2 BRIDGED PIPERAZINE AND PIPERIDINE DERIVATIVES AS CCR1 ANTAGONISTS Novartis AG (CH) 2007-06-13 — — EP disclosed
WO-2000050425-A1 POLYCYCLO HETEROCYCLIC DERIVATIVES AS ANTIINFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-08-31 — — WO disclosed
WO-2000034261-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 — — WO disclosed
WO-2000034260-A2 ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 — — WO disclosed
WO-2000034269-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 — — WO disclosed
WO-2000034268-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 — — WO disclosed
WO-2000034238-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 — — WO disclosed
WO-2000034258-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 — — WO disclosed
WO-2000034237-A2 ACETAMIDE AND SUBSTITUTED ACETAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190161449-A1 OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE STING1, IRF3, CGAS IDO1 592/4885EP300 1896/4885KAT8 3169/4885
US-20210002230-A1 OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE STING1, IRF3, CGAS IDO1 592/4885EP300 1896/4885KAT8 3169/4885
US-10745358-B2 Oxoacridinyl acetic acid derivatives and methods of use STING1, IRF3, CGAS IDO1 592/4885EP300 1896/4885KAT8 3169/4885
US-20070196270-A1 Compounds As Ccri Antagonists CCR1, CCR10, CCR4 IDO1 1357/4885EP300 173/4885KAT8 3376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.