Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.44 |
| ▸ | WNT3A | P56704 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL5238742 | 0.73 | MTNR1A (0.63) | MTNR1ACTNNB1WNT3AMTNR1BKDM4E | |
| SCHEMBL28264397 | 0.73 | MTNR1A (0.38) | MTNR1ACTNNB1WNT3AMTNR1B | |
| SCHEMBL6837924 | 0.72 | CTNNB1 (0.57) | MTNR1ACTNNB1WNT3AMTNR1BKDM4E | |
| SCHEMBL5236657 | 0.71 | MTNR1A (0.54) | MTNR1ACTNNB1WNT3AMTNR1BKDM4E | |
| SCHEMBL5218968 | 0.71 | MTNR1A (0.54) | MTNR1ACTNNB1WNT3AMTNR1BKDM4E | |
| SCHEMBL20978627 | 0.71 | MTNR1A (0.60) | MTNR1ACTNNB1WNT3AMTNR1BITGB2 | |
| SCHEMBL13533389 | 0.71 | MTNR1A (0.53) | MTNR1ACTNNB1WNT3AMTNR1BITGB2 | |
| SCHEMBL11358917 | 0.71 | MTNR1A (0.59) | MTNR1ACTNNB1WNT3AMTNR1BKDM4E | |
| SCHEMBL14237572 | 0.70 | MTNR1A (0.46) | MTNR1ACTNNB1WNT3AMTNR1BKDM4E | |
| SCHEMBL5405021 | 0.70 | MTNR1A (0.52) | MTNR1ACTNNB1WNT3AMTNR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244722-B2 | Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones | BIOVITRUM AB (SE) | 2007-07-17 | — | — | US | disclosed |
| EP-1534391-B1 | NOVEL PIPERAZINYL-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF 5-HT2A RECEPTOR-RELATED DISORDERS | BIOVITRUM AB (SE) | 2007-02-14 | — | — | EP | disclosed |
| EP-1534391-A1 | NOVEL PIPERAZINYL-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF 5-HT2A RECEPTOR-RELATED DISORDERS | Biovitrum AB (SE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004009586-A1 | NOVEL PIPERAZINYL-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF 5-HT2A RECEPTOR-RELATED DISORDERS | BIOVITRUM AB (SE) | 2004-01-29 | — | — | WO | disclosed |