Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.50 |
| ▸ | WNT3A | P56704 | 3/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368997 | 0.93 | MTNR1A (0.48) | MTNR1AKDM4ECTNNB1WNT3AMTNR1B | |
| SCHEMBL8951994 | 0.86 | KDM4C (0.41) | MTNR1AKDM4ECTNNB1WNT3AFAAH | |
| SCHEMBL5405021 | 0.84 | MTNR1A (0.52) | MTNR1AKDM4ECTNNB1WNT3AMTNR1B | |
| SCHEMBL3261062 | 0.79 | PARP1 (0.54) | MTNR1AKDM4EALDH1A1 | |
| SCHEMBL15514663 | 0.79 | MTNR1A (0.47) | MTNR1AKDM4EMTNR1B | |
| SCHEMBL11358917 | 0.78 | MTNR1A (0.59) | MTNR1AKDM4ECTNNB1WNT3AMTNR1B | |
| SCHEMBL15967624 | 0.76 | MTNR1A (0.51) | MTNR1AKDM4ECTNNB1WNT3AMTNR1B | |
| SCHEMBL6837924 | 0.76 | CTNNB1 (0.57) | MTNR1AKDM4ECTNNB1WNT3AMTNR1B | |
| SCHEMBL11469411 | 0.74 | ALDH1A1 (0.58) | MTNR1ACTNNB1WNT3AMTNR1BFAAH | |
| SCHEMBL11463501 | 0.74 | MTNR1A (0.50) | MTNR1AKDM4ECTNNB1WNT3AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318367-B1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | claimed |
| EP-2188282-B1 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-01-23 | — | — | EP | claimed |
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | claimed |