Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 4/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942576 | 0.95 | CYP19A1 (0.42) | PTGS1AKR1C3AKR1C2POLBCYP1A2 | |
| SCHEMBL11471233 | 0.83 | PTGS1 (0.59) | PTGS1AKR1C3AKR1C2POLBCYP1A2 | |
| SCHEMBL2615110 | 0.82 | CYP1A2 (0.64) | CYP1A2SLC6A2SLC6A3KDM4ENPC1 | |
| SCHEMBL9852730 | 0.81 | MAOB (0.55) | MAOAMAOB | |
| SCHEMBL265881 | 0.81 | L3MBTL1 (0.56) | CYP1A2SLC6A3KDM4ESMN1; SMN2CYP2A6 | |
| SCHEMBL11471175 | 0.81 | GAA (0.51) | PTGS1AKR1C3AKR1C2NPC1MAPT | |
| SCHEMBL48545 | 0.80 | GAA (0.53) | POLBKDM4ELMNATP53CYP3A4 | |
| SCHEMBL5692811 | 0.79 | ALOX5 (0.51) | PTGS1AKR1C3AKR1C2POLBCYP1A2 | |
| SCHEMBL18537208 | 0.79 | L3MBTL1 (0.51) | PTGS1AKR1C3AKR1C2CYP1A2SLC6A3 | |
| SCHEMBL28141362 | 0.79 | KDM4E (0.42) | PTGS1AKR1C3AKR1C2POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851232-A2 | DIHYDROIMIDAZOTHIAZOLE DERIVATIVES | Prosidion Limited (GB) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006085118-A2 | DIHYDROIMIDAZOTHIAZOLE DERIVATIVES | PROSIDION LIMITED (GB) | 2006-08-17 | — | — | WO | disclosed |