Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29159149 | 0.82 | COMT (0.59) | COMTALDH1A1HSD17B10CYP1A2ALOX15 | |
| SCHEMBL30978770 | 0.82 | COMT (0.59) | COMTALDH1A1HSD17B10CYP1A2ALOX15 | |
| SCHEMBL29228470 | 0.81 | COMT (0.57) | COMTALDH1A1HSD17B10CYP1A2ALOX15 | |
| Potassium Ion SCHEMBL30960548 | 0.79 | ALDH1A1 (0.41) | COMTALDH1A1HSD17B10CYP1A2ALOX15 | |
| SCHEMBL11043739 | 0.77 | NCF1 (0.47) | ALDH1A1HSD17B10CYP1A2ALOX15HIF1A | |
| SCHEMBL4325354 | 0.76 | TSHR (0.54) | TRPV4ALDH1A1ALOX15HIF1ALMNA | |
| Hydrochloric Acid SCHEMBL30871757 | 0.74 | LMNA (0.55) | TRPV4ALDH1A1ALOX15HIF1ALMNA | |
| SCHEMBL23379789 | 0.72 | MEN1 (0.50) | COMTALDH1A1HSD17B10CYP1A2ALOX15 | |
| SCHEMBL17960045 | 0.72 | COMT (0.47) | TRPV4COMTALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL11274678 | 0.72 | COMT (0.73) | COMTALDH1A1FTOLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558479-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-05-28 | — | — | EP | disclosed |
| WO-2024017858-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |