Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 16/20 | 0.51 |
| ▸ | RAB9A | P51151 | 15/20 | 0.51 |
| ▸ | NPC1 | O15118 | 14/20 | 0.51 |
| ▸ | MAPT | P10636 | 12/20 | 0.51 |
| ▸ | MEN1 | O00255 | 9/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | MITF | O75030 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10027943 | 0.74 | NOX1 (0.47) | GAARAB9ANPC1MAPTMEN1 | |
| SCHEMBL3706136 | 0.73 | SMN1; SMN2 (0.42) | GAARAB9ANPC1MAPTMEN1 | |
| SCHEMBL18731443 | 0.72 | GAA (0.54) | GAARAB9ANPC1MAPTMEN1 | |
| SCHEMBL23728221 | 0.71 | NOX1 (0.49) | GAARAB9ANPC1MAPTMEN1 | |
| SCHEMBL23728219 | 0.71 | NOX1 (0.49) | GAARAB9ANPC1MAPTMEN1 | |
| SCHEMBL265614 | 0.70 | TP53 (0.70) | RAB9ANPC1MAPTSMN1; SMN2HPGD | |
| SCHEMBL7490760 | 0.70 | MAPT (0.48) | GAARAB9ANPC1MAPTMEN1 | |
| SCHEMBL16792666 | 0.70 | GAA (0.48) | GAARAB9ANPC1MAPTMEN1 | |
| SCHEMBL872409 | 0.70 | HCAR3 (0.57) | SMN1; SMN2MITFALDH1A1KCNH2MAPK1 | |
| SCHEMBL455156 | 0.69 | HCAR3 (0.55) | GAAMAPTKMT2ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761539-A1 | INDOLE DERIVATIVE AND USE FOR TREATMENT OF CANCER | Takeda Pharmaceutical Company Limited (JP) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005118587-A1 | INDOLE DERIVATIVE AND USE FOR TREATMENT OF CANCER | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-12-15 | — | — | WO | disclosed |