Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 11/20 | 0.42 |
| ▸ | RAB9A | P51151 | 11/20 | 0.42 |
| ▸ | GAA | P10253 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MITF | O75030 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713072 | 0.81 | NOX1 (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL23728221 | 0.81 | NOX1 (0.49) | ALDH1A1MAPK1NPC1RAB9AGAA | |
| SCHEMBL23728219 | 0.81 | NOX1 (0.49) | ALDH1A1MAPK1NPC1RAB9AGAA | |
| SCHEMBL3707004 | 0.78 | GRK2 (0.41) | SMN1; SMN2ALDH1A1MAPK1RAB9AGAA | |
| SCHEMBL5239605 | 0.73 | GAA (0.51) | SMN1; SMN2ALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL2568204 | 0.70 | CA1 (0.60) | SMN1; SMN2ALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL518614 | 0.69 | NOS1 (0.46) | SMN1; SMN2ALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL6740486 | 0.69 | NOS1 (0.48) | SMN1; SMN2ALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL1803092 | 0.68 | ADRA2A (0.53) | SMN1; SMN2ALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL10027943 | 0.67 | NOX1 (0.47) | SMN1; SMN2ALDH1A1MAPK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102365020-B | Pyridazinone compounds | TAKEDA PHARMACEUTICAL | 2014-07-30 | — | — | CN | disclosed |
| EP-2393360-A1 | PYRIDAZINONE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090737-A1 | PYRIDAZINONE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-12 | — | — | WO | disclosed |