Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 2/20 | 0.59 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.59 |
| ▸ | CCR1 | P32246 | 2/20 | 0.52 |
| ▸ | CCR5 | P51681 | 2/20 | 0.52 |
| ▸ | CCR8 | P51685 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18029399 | 0.86 | PSMD14 (0.59) | PSMD14COPS5CCR1CCR5CCR8 | |
| SCHEMBL16133354 | 0.85 | PSMD14 (0.54) | PSMD14COPS5CCR1CCR5CCR8 | |
| SCHEMBL1337689 | 0.82 | HTR1A (0.61) | PSMD14COPS5CCR1CCR5CCR8 | |
| SCHEMBL24612894 | 0.81 | KDM4E (0.49) | L3MBTL1KMT2AMEN1HTR1AADRA1D | |
| SCHEMBL3691358 | 0.81 | HTR1A (0.45) | KMT2AMEN1HTR1AADRA1DADRA1A | |
| SCHEMBL11428540 | 0.81 | NR4A2 (0.53) | L3MBTL1KMT2AMEN1HTR1AADRA1D | |
| SCHEMBL10366160 | 0.81 | PSMD14 (0.53) | PSMD14COPS5CCR1CCR5CCR8 | |
| SCHEMBL16132603 | 0.81 | MAPT (0.56) | PSMD14COPS5CCR1CCR5CCR8 | |
| SCHEMBL30423646 | 0.79 | PSMD14 (0.54) | PSMD14COPS5CCR1CCR5CCR8 | |
| SCHEMBL29035107 | 0.79 | PSMD14 (0.54) | PSMD14COPS5CCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |
| US-7087626-B2 | Pyrrole derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2006-08-08 | — | — | US | disclosed |