Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5242494 | 0.93 | KCNA5 (0.55) | KCNA5DRD2DRD3ALDH1A1KDM4E | |
| SCHEMBL5240284 | 0.91 | KCNA5 (0.55) | KCNA5DRD2DRD3ALDH1A1KDM4E | |
| SCHEMBL5244362 | 0.89 | KCNA5 (0.52) | KCNA5DRD2DRD3ALDH1A1KDM4E | |
| SCHEMBL5241692 | 0.89 | KCNA5 (0.52) | KCNA5DRD2DRD3ALDH1A1KDM4E | |
| SCHEMBL5242627 | 0.88 | KCNA5 (0.53) | KCNA5DRD2DRD3ALDH1A1KDM4E | |
| SCHEMBL6624933 | 0.86 | DRD2 (0.56) | KCNA5DRD2DRD3ALDH1A1KDM4E | |
| SCHEMBL5242861 | 0.85 | KCNA5 (0.51) | KCNA5DRD2DRD3ALDH1A1KDM4E | |
| SCHEMBL5905534 | 0.78 | CHRNA7 (0.47) | KCNA5DRD2DRD3ALDH1A1KDM4E | |
| SCHEMBL5240305 | 0.78 | LDHA (0.51) | KCNA5DRD2DRD3MEN1KMT2A | |
| SCHEMBL5241918 | 0.77 | LDHA (0.50) | DRD2DRD3MEN1KMT2ALDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | claimed |