Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201146 | 0.85 | MAPK1 (0.54) | CHEK2SSTR2CHRNB4CHRNA3HPGD | |
| SCHEMBL4263220 | 0.82 | CHEK2 (0.54) | CHEK2SSTR2CHRNB4CHRNA3HPGD | |
| SCHEMBL5239690 | 0.82 | SSTR2 (0.41) | SSTR2HSP90AA1HSP90AB1CHRNB4CHRNA3 | |
| SCHEMBL5247466 | 0.81 | HTR2A (0.47) | CHEK2SSTR2 | |
| SCHEMBL5243021 | 0.78 | SSTR2 (0.50) | CHEK2SSTR2 | |
| SCHEMBL5243204 | 0.77 | HTR2A (0.46) | CHEK2 | |
| SCHEMBL6027576 | 0.77 | MAP2K1 (0.46) | CHEK2CHRNB4CHRNA3 | |
| SCHEMBL11459124 | 0.76 | SLC6A2 (0.53) | CHRNB4CHRNA3PIM1PIM2 | |
| SCHEMBL5243165 | 0.75 | HTR2A (0.47) | CHEK2SSTR2 | |
| SCHEMBL5152692 | 0.74 | CHRNA3 (0.54) | CHRNB4CHRNA3DPP4PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828207-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066174-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-06-22 | — | — | WO | disclosed |