Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.30 |
| ▸ | MELK | Q14680 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263693 | 0.87 | CHRNB2 (0.40) | GRM5TLR7POLBMAPK14KDM4E | |
| SCHEMBL31036005 | 0.87 | CHRNB2 (0.40) | GRM5TLR7POLBMAPK14KDM4E | |
| SCHEMBL17567286 | 0.81 | GRM5 (0.45) | GRM5TLR7KDM4EHSP90AA1CHRNB2 | |
| Biphenyl SCHEMBL27555363 | 0.80 | CYP1A2 (0.37) | GRM5TLR7ASIC3MAPK14KDM4E | |
| SCHEMBL16254036 | 0.78 | TLR7 (0.35) | GRM5TLR7MAPK14 | |
| SCHEMBL31286309 | 0.76 | GRM5 (0.59) | GRM5POLBHAO1KDM4ENAPRT | |
| SCHEMBL15870932 | 0.76 | GRM5 (0.59) | GRM5POLBHAO1KDM4ENAPRT | |
| SCHEMBL28148504 | 0.76 | GRM5 (0.47) | GRM5POLBHAO1KDM4EHSP90AA1 | |
| SCHEMBL102810 | 0.73 | GRM5 (0.45) | GRM5ASIC3 | |
| SCHEMBL31036128 | 0.73 | GRM5 (0.45) | GRM5ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975988-B2 | Epoxy resins comprising a pyrazine-containing compound | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-05-22 | — | — | US | disclosed |
| US-9975988-B2 | Epoxy resins comprising a pyrazine-containing compound | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-05-22 | — | — | US | disclosed |
| US-20160068627-A1 | EPOXY RESINS COMPRISING A PYRAZINE-CONTAINING COMPOUND | 3M INNOVATIVE PROPERTIES COMPANY | 2016-03-10 | — | — | US | disclosed |
| US-20160068627-A1 | EPOXY RESINS COMPRISING A PYRAZINE-CONTAINING COMPOUND | 3M INNOVATIVE PROPERTIES COMPANY | 2016-03-10 | — | — | US | disclosed |
| WO-2014186151-A1 | EPOXY RESINS COMPRISING A PYRAZINE-CONTAINING COMPOUND | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-11-20 | — | — | WO | disclosed |
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | disclosed |
| US-20060009456-A1 | Aryl-substituted piperazine derivatives | NEUROGEN CORPORATION | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009456-A1 | Aryl-substituted piperazine derivatives | MCHR1, MCHR2, PRLHR | GRM5 126/4885TLR7 1427/4885POLB 4525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.