Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560575 | 0.82 | TLR8 (0.47) | L3MBTL1TLR8MEN1KMT2ASLC2A1 | |
| SCHEMBL15413796 | 0.79 | MAPK1 (0.50) | L3MBTL1MEN1KMT2ATSHRALOX5 | |
| SCHEMBL16466572 | 0.76 | TLR8 (0.45) | L3MBTL1TLR8MEN1KMT2ASLC2A1 | |
| SCHEMBL1127908 | 0.74 | TLR8 (0.50) | L3MBTL1TLR8MEN1KMT2ASLC2A1 | |
| SCHEMBL29694174 | 0.74 | GPR84 (0.44) | L3MBTL1TLR8SLC2A1ALOX5ALDH1A1 | |
| SCHEMBL644629 | 0.74 | GPR84 (0.44) | L3MBTL1TLR8SLC2A1ALOX5ALDH1A1 | |
| SCHEMBL28448150 | 0.73 | S1PR1 (0.46) | TLR8MEN1KMT2AIDO1TSHR | |
| SCHEMBL10786002 | 0.73 | TSHR (0.41) | L3MBTL1TLR8MEN1KMT2ASLC2A1 | |
| SCHEMBL19612229 | 0.72 | MEN1 (0.47) | TLR8MEN1KMT2AALOX5ALDH1A1 | |
| SCHEMBL935476 | 0.72 | TLR8 (0.45) | L3MBTL1TLR8MEN1KMT2ASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830841-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006068992-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-06-29 | — | — | WO | disclosed |