Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13202699 | 0.88 | EPAS1 (0.43) | CASP6EPAS1TLR8TLR7CYP1A2 | |
| SCHEMBL13202694 | 0.84 | EPAS1 (0.52) | EPAS1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL2977602 | 0.82 | S1PR1 (0.47) | S1PR1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL2978543 | 0.81 | TMEM97 (0.53) | SIGMAR1SMN1; SMN2CYP2D6CYP2C19 | |
| SCHEMBL2976630 | 0.81 | LMNA (0.51) | SMN1; SMN2 | |
| SCHEMBL13202695 | 0.81 | EPAS1 (0.52) | EPAS1 | |
| SCHEMBL3854234 | 0.81 | SMN1; SMN2 (0.51) | S1PR2CASP6EPAS1SMN1; SMN2 | |
| SCHEMBL13202686 | 0.80 | THRA (0.46) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL13202796 | 0.79 | EPAS1 (0.56) | EPAS1SMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13202726 | 0.79 | ACHE (0.42) | EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776847-B2 | Benzisothiazoles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7776847-B2 | Benzisothiazoles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| EP-1853573-A1 | BENZISOTHIAZOLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION | Rigel Pharmaceuticals, Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006091858-A1 | BENZISOTHIAZOLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION | RIGEL PHARMACEUTICALS, INC. (US) | 2006-08-31 | — | — | WO | disclosed |