Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 13/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.49 |
| ▸ | DHFR | P00374 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447978 | 0.84 | ADORA1 (0.69) | ADORA1ADORA2ADHFRADORA2BKMT2A | |
| SCHEMBL5453709 | 0.79 | ADORA1 (0.48) | ADORA1ADORA2ADHFRCCNT1CCNA2 | |
| SCHEMBL5241134 | 0.79 | CCNA2 (0.47) | ADORA1ADORA2ADHFRCCNT1CCNA2 | |
| SCHEMBL5240638 | 0.78 | ADORA2B (0.61) | ADORA1ADORA2BCLK4 | |
| SCHEMBL5459579 | 0.78 | ADORA1 (0.55) | ADORA1ADORA2ADHFRCCNT1CCNA2 | |
| SCHEMBL4048469 | 0.77 | ADORA2A (0.60) | ADORA1ADORA2ACCNT1CCNA2CDK2 | |
| SCHEMBL5460965 | 0.77 | ADORA1 (0.53) | ADORA1ADORA2ADHFRCCNT1CCNA2 | |
| SCHEMBL4052237 | 0.77 | ADORA2A (0.44) | ADORA1ADORA2ACCNT1CCNA2CDK2 | |
| SCHEMBL5454611 | 0.76 | ADORA1 (0.45) | ADORA1ADORA2ADHFRADORA2B | |
| SCHEMBL1445172 | 0.76 | KMO (0.51) | CDK2KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265273-A1 | Pyrimidin-2-Amine Derivatives and Their Use as A2b Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265273-A1 | Pyrimidin-2-Amine Derivatives and Their Use as A2b Adenosine Receptor Antagonists | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ADORA2A 2/4885DHFR 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.