Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054100 | 0.82 | CCNA2 (0.47) | CCNA2CDK2CCNT1CDK9ADORA1 | |
| SCHEMBL3812923 | 0.80 | KMO (0.55) | CCNA2CDK2CCNT1CDK9LMNA | |
| SCHEMBL5239785 | 0.79 | MAP4K4 (0.45) | CCNA2CDK2ADORA1KDRAURKB | |
| SCHEMBL5741625 | 0.79 | CCNT1 (0.42) | CCNA2CDK2CCNT1CDK9ADORA1 | |
| SCHEMBL5242020 | 0.79 | ADORA1 (0.49) | CCNA2CDK2CCNT1CDK9ADORA1 | |
| SCHEMBL5819641 | 0.77 | TGFBR1 (0.45) | CCNA2CDK2LMNACSNK1ECDK5 | |
| SCHEMBL5459579 | 0.77 | ADORA1 (0.55) | CCNA2CDK2CCNT1CDK9ADORA1 | |
| SCHEMBL5818427 | 0.77 | KDM4E (0.42) | CCNA2CDK2ADORA1LMNAADORA2A | |
| SCHEMBL5451407 | 0.76 | ADORA1 (0.55) | ADORA1ADORA2AMAPK14MAPK13MAPK12 | |
| SCHEMBL5460965 | 0.76 | ADORA1 (0.53) | CCNA2CDK2CCNT1CDK9ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265273-A1 | Pyrimidin-2-Amine Derivatives and Their Use as A2b Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2007-11-15 | — | — | US | disclosed |
| EP-1668000-A1 | PYRIMIDIN-2-AMINE DERIVATIVES AND THEIR USE AS A2B ADENOSINE RECEPTOR ANTAGONISTS | Almirall Prodesfarma, S.A. (ES) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005040155-A1 | PYRIMIDIN-2-AMINE DERIVATES AND THEIR USE AS A2B ADENOSINE RECEPTOR ANTAGONISTS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265273-A1 | Pyrimidin-2-Amine Derivatives and Their Use as A2b Adenosine Receptor Antagonists | ADORA2B, ADORA2A, ADORA1 | CCNA2 209/4885CDK2 196/4885CCNT1 1683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.