Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243815 | 0.84 | ALDH1A1 (0.52) | ALDH1A1TSHRACACBTNFNOD2 | |
| SCHEMBL2025437 | 0.77 | GRM2 (0.47) | ALDH1A1TSHRHTR2CTRPV1 | |
| SCHEMBL5239908 | 0.77 | ALDH1A1 (0.52) | ALDH1A1TSHRTNFNOD2NOD1 | |
| SCHEMBL5279985 | 0.77 | CHRM5 (0.48) | ALDH1A1TSHRSLC6A4SLC6A3ACACB | |
| SCHEMBL5243311 | 0.75 | KMT2A (0.44) | DRD4DRD2DRD3KCNH2 | |
| SCHEMBL5240643 | 0.75 | ALDH1A1 (0.50) | ALDH1A1TSHRACACBTNFNOD2 | |
| SCHEMBL5245082 | 0.75 | KDM4E (0.40) | ALDH1A1DRD4DRD2DRD3KCNH2 | |
| SCHEMBL5241430 | 0.74 | ALDH1A1 (0.52) | ALDH1A1TSHRDRD4DRD2DRD3 | |
| SCHEMBL5243643 | 0.73 | ALDH1A1 (0.41) | ALDH1A1TSHRDRD4TNFNOD2 | |
| SCHEMBL5240721 | 0.73 | ALDH1A1 (0.50) | ALDH1A1TSHRDRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |