Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 5/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2026199 | 0.80 | CHRM5 (0.42) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL5243815 | 0.78 | ALDH1A1 (0.52) | ALDH1A1PRCPTSHRTNFNOD2 | |
| SCHEMBL27684984 | 0.78 | SCN9A (0.38) | ALDH1A1PRCPMMP1MMP2MMP3 | |
| SCHEMBL2024371 | 0.74 | GRM2 (0.49) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL12442167 | 0.73 | GRM2 (0.42) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL5243418 | 0.73 | ALDH1A1 (0.50) | ALDH1A1TSHRTNFNOD2NOD1 | |
| SCHEMBL27703936 | 0.72 | SCN9A (0.40) | ALDH1A1MMP1MMP2MMP3MMP9 | |
| SCHEMBL5239908 | 0.71 | ALDH1A1 (0.52) | ALDH1A1TSHRTNFNOD2NOD1 | |
| SCHEMBL5279985 | 0.71 | CHRM5 (0.48) | ALDH1A1TSHRCHRM5KCNH2RAB9A | |
| SCHEMBL2023227 | 0.69 | LSS (0.46) | ALDH1A1P2RY1TNFNOD2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | claimed |