Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2026495 | 0.80 | CHRM5 (0.53) | CHRM5ALDH1A1ABL1BCRNTRK1 | |
| SCHEMBL5243815 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TSHRKCNH2ACACBHTR2C | |
| SCHEMBL5243418 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TSHRKCNH2ACACBHTR2C | |
| SCHEMBL5242171 | 0.73 | ALDH1A1 (0.43) | CHRM5ALDH1A1TSHRACACBHTR2C | |
| SCHEMBL5239908 | 0.72 | ALDH1A1 (0.52) | ALDH1A1TSHR | |
| SCHEMBL5240643 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TSHRKCNH2ACACBHTR2C | |
| SCHEMBL5243643 | 0.71 | ALDH1A1 (0.41) | CHRM5ALDH1A1TSHRKCNH2RAB9A | |
| SCHEMBL5241430 | 0.70 | ALDH1A1 (0.52) | ALDH1A1TSHRKCNH2ACACBHTR2C | |
| SCHEMBL5240721 | 0.69 | ALDH1A1 (0.50) | CHRM5ALDH1A1TSHRKCNH2ACACB | |
| SCHEMBL2024736 | 0.68 | ABL1 (0.45) | CHRM5ALDH1A1ABL1BCRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | claimed |
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |