Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | CSF1R | P07333 | 7/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243561 | 0.85 | EGFR (0.46) | EGFRCSF1RPDGFRB | |
| SCHEMBL5248227 | 0.84 | EGFR (0.38) | EGFRCSF1RPDGFRBMEN1KMT2A | |
| SCHEMBL17815795 | 0.79 | MAP4K4 (0.36) | EGFRCSF1RPDGFRBKMT2A | |
| SCHEMBL8856262 | 0.76 | HTT (0.42) | MEN1KMT2AMAPT | |
| SCHEMBL10501817 | 0.75 | MAPT (0.46) | EGFRCSF1RPDGFRBPDGFRAMEN1 | |
| SCHEMBL5244451 | 0.74 | MAPT (0.58) | EGFRCSF1RPDGFRBPDGFRAMEN1 | |
| SCHEMBL21159117 | 0.72 | NUDT1 (0.35) | EGFRCSF1RKMT2AMAPT | |
| SCHEMBL27732861 | 0.71 | CSF1R (0.50) | EGFRCSF1RPDGFRBPDGFRAMEN1 | |
| SCHEMBL10952100 | 0.70 | EGFR (0.57) | EGFRCSF1RPDGFRBPDGFRAMEN1 | |
| SCHEMBL3126298 | 0.70 | EGFR (0.60) | EGFRCSF1RPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848506-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | Attenuon, LLC (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089298-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | ATTENUON, LLC (US) | 2006-08-24 | — | — | WO | disclosed |