Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.38 |
| ▸ | CSF1R | P07333 | 6/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243561 | 0.86 | EGFR (0.46) | EGFRCSF1RPDGFRBKDRALDH1A1 | |
| SCHEMBL5244332 | 0.84 | EGFR (0.53) | EGFRCSF1RPDGFRBMEN1KMT2A | |
| SCHEMBL17815795 | 0.80 | MAP4K4 (0.36) | EGFRCSF1RPDGFRBKDRSMN1; SMN2 | |
| SCHEMBL5244192 | 0.76 | MAPT (0.43) | EGFRCSF1RLMNASMN1; SMN2RXRA | |
| SCHEMBL8856262 | 0.74 | HTT (0.42) | ALDH1A1LMNAHTTMEN1TP53 | |
| SCHEMBL27712681 | 0.73 | CYP1A2 (0.41) | EGFRCSF1RPDGFRBKDRALDH1A1 | |
| SCHEMBL21159595 | 0.73 | RAB9A (0.38) | CSF1RALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL9509773 | 0.72 | EGFR (0.43) | EGFRCSF1RPDGFRBKDRALDH1A1 | |
| SCHEMBL28004896 | 0.67 | EGFR (0.74) | EGFRCSF1RALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13338132 | 0.66 | APP (0.52) | ALDH1A1HTTMEN1CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848506-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | Attenuon, LLC (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089298-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | ATTENUON, LLC (US) | 2006-08-24 | — | — | WO | disclosed |