Citric Acid

Citric Acid

SCHEMBL524443

O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Ag]

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.40
ALDH1A1 P00352 2/20 0.88
HMGCR P04035 1/20 0.46
CHRM1 P11229 1/20 0.46
TBXA2R P21731 1/20 0.46
ADRA1A P35348 1/20 0.46
TSHR P16473 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C19 P33261 1/20 0.43
HIF1A Q16665 1/20 0.43
ACLY P53396 4/20 0.42
KDM4E B2RXH2 2/20 0.42
LMNA P02545 2/20 0.42
MAPT P10636 1/20 0.42
ALOX15 P16050 1/20 0.42
SLC13A5 Q86YT5 4/20 0.41
CPT2 P23786 1/20 0.41
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL15054707 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL33987 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL11039957 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL16685075 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL22721 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL23062790 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL12542739 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL20535729 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL20607531 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL3692334 0.97 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12121691-B2 Antimicrobial caps for medical connectors BECTON, DICKINSON AND COMPANY (US) 2024-10-22 US claimed
WO-2023091145-A1 IMPROVED BIOSYNTHETIC WOUND AND BURN DRESSING WITH SILVER-BASED BROAD ANTIMICROBIAL ACTIVITY WOODROOF E AUBREY (US) 2023-05-25 WO claimed
EP-4121236-A1 COMPOSITIONS AND METHODS FOR PARTICLE THREE-DIMENSIONAL PRINTING Holo, Inc. (US) 2023-01-25 EP claimed
EP-3466481-B1 ANTIMICROBIAL CAPS FOR MEDICAL CONNECTORS BECTON DICKINSON CO (US) 2022-11-02 EP claimed
US-20220339424-A1 ANTIMICROBIAL CAPS FOR MEDICAL CONNECTORS BECTON, DICKINSON AND COMPANY 2022-10-27 US claimed
US-11357965-B2 Antimicrobial caps for medical connectors BECTON, DICKINSON AND COMPANY (US) 2022-06-14 US claimed
WO-2022046930-A1 ANTIVIRAL AND ANTIMICROBIAL PROTECTIVE FILMS WITH MICROSTRUCTURE DETERRENTS LUMENCO, LLC (US) 2022-03-03 WO claimed
US-20220063178-A1 ANTIVIRAL AND ANTIMICROBIAL PROTECTIVE FILMS WITH MICROSTRUCTURE DETERRENTS COMBINED WITH THERMALLY ELASTOMERIC AND EMBEDDED CHEMICAL ANTI-BACTERIAL OR ANTI-VIRAL AGENTS MICROBEPROOF, LLC 2022-03-03 US claimed
CN-111150931-B Antibacterial cap for medical connector 贝克顿·迪金森公司 2021-10-19 CN claimed
WO-2021188638-A1 COMPOSITIONS AND METHODS FOR PARTICLE THREE-DIMENSIONAL PRINTING HOLO, INC. (US) 2021-09-23 WO claimed
US-9060511-B2 Compositions of dibromomalanomide and their use as biocides ROHM AND HAAS COMPANY (US) 2015-06-23 US claimed
CN-103068229-B Dibromomalonamide compositions and their use as biocides DOW GLOBAL TECHNOLOGIES INC 2015-05-20 CN claimed
EP-2582238-B1 COMPOSITIONS OF DIBROMOMALONAMIDE AND THEIR USE AS BIOCIDES DOW GLOBAL TECHNOLOGIES LLC (US) 2014-06-04 EP claimed
US-20130142886-A1 COMPOSITIONS OF DIBROMOMALANOMIDE AND THEIR USE AS BIOCIDES DOW GLOBAL TECHNOLOGIES LLC (US) 2013-06-06 US claimed
EP-2582238-A1 COMPOSITIONS OF DIBROMOMALONAMIDE AND THEIR USE AS BIOCIDES Dow Global Technologies LLC (US) 2013-04-24 EP claimed
CN-103068229-A Dibromomalonamide compositions and their use as biocides DOW GLOBAL TECHNOLOGIES LLC 2013-04-24 CN claimed
US-20120225126-A1 SOLID STATE SYNTHESIS METHOD OF SILVER NANOPARTICLES, AND SILVER NANOPARTICLES SYNTHESIZED THEREBY GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2012-09-06 US claimed
WO-2012021340-A1 COMPOSITIONS OF DIBROMOMALONAMIDE AND THEIR USE AS BIOCIDES DOW GLOBAL TECHNOLOGIES LLC (US) 2012-02-16 WO claimed
WO-2006056570-A1 METHOD FOR PRODUCING LIVE FOOD WATER ORGANISMS IN THE PRESENCE OF AN ANTIBACTERIAL INVE TECHNOLOGIES NV (BE) 2006-06-01 WO claimed
EP-1658776-A1 Method for producing live food water organisms in the presence of an antibacterial Inve Technologies N.V. (BE) 2006-05-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130142886-A1 COMPOSITIONS OF DIBROMOMALANOMIDE AND THEIR USE AS BIOCIDES DDT, BCHE, MGAM MEN1 2489/4885ALDH1A1 1719/4885HMGCR 4503/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.